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Title: OS-9: another piece in the HIF complex story. Author: Flashman E, McDonough MA, Schofield CJ. Journal: Mol Cell; 2005 Feb 18; 17(4):472-3. PubMed ID: 15721249. Abstract: In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).[Abstract] [Full Text] [Related] [New Search]