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  • Title: The role of insulin and IGF-1 signaling in longevity.
    Author: Katic M, Kahn CR.
    Journal: Cell Mol Life Sci; 2005 Feb; 62(3):320-43. PubMed ID: 15723168.
    Abstract:
    There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
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