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  • Title: Asymmetric synthesis of (+)-(S,S)-reboxetine via a new (S)-2-(hydroxymethyl)morpholine preparation.
    Author: Brenner E, Baldwin RM, Tamagnan G.
    Journal: Org Lett; 2005 Mar 03; 7(5):937-9. PubMed ID: 15727479.
    Abstract:
    (S,S)-Reboxetine was synthesized stereospecifically in 30% overall yield and 99% ee in eight steps. Key steps were selective oxidation of an N-protected hydroxymethylmorpholine and aryl-chromium-mediated aromatic nucleophilic substitution. [structure: see text]
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