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  • Title: The lectin-like oxidized low-density lipoprotein receptor and its role in atherosclerosis.
    Author: Cilingiroglu M, Ozer K.
    Journal: Curr Atheroscler Rep; 2005 Mar; 7(2):103-7. PubMed ID: 15727724.
    Abstract:
    The lectin-like oxidized low-density lipoprotein receptor (LOX-1), a recently identified receptor that plays a role in the uptake of oxidized low-density lipoproteins into endothelial cells, has a pivotal role in the pathogenesis of atherosclerosis. The ways this receptor takes part in atherosclerosis is through uptake of oxidized low-density lipoproteins into endothelial cells, smooth muscle cells, and macrophages; decreasing nitric oxide production; increasing inflammatory cell recruitment; and increasing smooth muscle cell proliferation. LOX-1 is inducible and regulated by multiple factors known to underlie atherogenesis. Further understanding of this receptor may lead to potential molecular targets for prevention and treatment of atherosclerosis.
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