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  • Title: Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
    Author: Kamal A, Devaiah V, Reddy KL, Kumar MS.
    Journal: Bioorg Med Chem; 2005 Mar 15; 13(6):2021-9. PubMed ID: 15727856.
    Abstract:
    Fluoroquinolones have been synthesized and linked to DC-81 at C8 position through different alkyl chain spacers. These PBD conjugates have exhibited good DNA binding affinity, and a representative compound shows promising in vitro anticancer activity.
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