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  • Title: New naphthylcombretastatins. Modifications on the ethylene bridge.
    Author: Sánchez Maya AB, Pérez-Melero C, Salvador N, Peláez R, Caballero E, Medarde M.
    Journal: Bioorg Med Chem; 2005 Mar 15; 13(6):2097-107. PubMed ID: 15727863.
    Abstract:
    Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
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