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  • Title: Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice.
    Author: Ninomiya M, Mikamo H, Tanaka K, Watanabe K, Tamaya T.
    Journal: J Antimicrob Chemother; 2005 Apr; 55(4):587-90. PubMed ID: 15728144.
    Abstract:
    OBJECTIVES: We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model. METHODS: We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously. RESULTS AND CONCLUSIONS: Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.
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