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  • Title: Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
    Author: Ying C, Holy A, Hocková D, Havlas Z, De Clercq E, Neyts J.
    Journal: Antimicrob Agents Chemother; 2005 Mar; 49(3):1177-80. PubMed ID: 15728921.
    Abstract:
    Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.
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