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  • Title: Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones.
    Author: Cui NQ, Zhang SK, Cui YF, Li DH, Chen C, Wu XZ.
    Journal: Hepatobiliary Pancreat Dis Int; 2005 Feb; 4(1):117-20. PubMed ID: 15730934.
    Abstract:
    BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2(SCP2) participates in cholesterol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in patients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2mRNA was studied in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-polymerase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in patients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.
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