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  • Title: [Lipid peroxidation and activity of antioxidant enzymes in thyroidectomized rats].
    Author: Hrinevych IuIa, Bendiuh HD, Bilokin' IuM, Trembach OM.
    Journal: Fiziol Zh (1994); 2004; 50(6):83-7. PubMed ID: 15732763.
    Abstract:
    The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.
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