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  • Title: [Ultrastructural characteristics of lipid droplets in rat adrenocortical cells from zona fasciculata-reticularis].
    Author: Tokar SL, Koval' LM, Iavors'ka OM, Luk'ianets' OO.
    Journal: Fiziol Zh (1994); 2004; 50(6):107-13. PubMed ID: 15732767.
    Abstract:
    One day cultured adrenocortical cells from zona fasciculata-reticularis were used in morphological experiments. The electron-microscopic and imaging analysis methods were used for the investigation of intracellular ultrastructure of these cells. Experiments which conducted in control conditions, allowed us to allocate three types of cells which differed by ultrastructure of the mitochondria, lipid droplets, smooth endoplasmic reticulum and dense bodies. It was shown that lipid droplets with light and homogeneous matrix, met more often in cells with morphological attributes of high intensity of steroidogenesis. On the contrary, lipid droplets, with dark matrix and a dense edging, met more often in cells which having morphological attributes-of low intensity of steroidogenesis. Ionophore A23187 or adrenocorticotropic hormone application resulted in reduction of lipid droplets diameter and in simultaneous increase in density of their arrangement in cytoplasm. At the same time droplet matrix became light and homogeneous in all cells. Thus, the ultrastructure of lipid droplet matrix is sensitive to change of calcium ions concentration in cytoplasm. Processes which result in change of lipid droplet ultrastructure, probably, are connected to steroidogenesis, nevertheless, this question requires further investigation. The lipid droplets" ability to form morphological contacts with smooth endoplasmic reticulum, mitochondria, nuclear and cellular membranes is also discussed.
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