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  • Title: Periadolescent nicotine exposure causes heterologous sensitization to cocaine reinforcement.
    Author: McMillen BA, Davis BJ, Williams HL, Soderstrom K.
    Journal: Eur J Pharmacol; 2005 Feb 21; 509(2-3):161-4. PubMed ID: 15733551.
    Abstract:
    There is increasing concern that abuse of tobacco during periadolescence increases the potential for later abuse of other drugs. To test this hypothesis, Sprague-Dawley rats received once-daily injections of either water or 0.4 mg/kg nicotine from postnatal day 35 through 44. Beginning on postnatal day 80, animals were tested in a 12-day cocaine-induced conditioned place preference (CPP) paradigm. Prior nicotine treatment enhanced the dose-response to cocaine. CPP training with 3.0 mg/kg i.p. cocaine increased time in drug-paired chambers by 50% in control rats and 94% in nicotine-exposed animals. Thus, periadolescent nicotine exposure produced long-term sensitization to an indirect-acting dopamine agonist.
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