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  • Title: Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the athymic mouse model.
    Author: Honsawek S, Powers RM, Wolfinbarger L.
    Journal: Cell Tissue Bank; 2005; 6(1):13-23. PubMed ID: 15735897.
    Abstract:
    A correlation between extractable bone morphogenetic proteins (BMPs) in demineralized bone matrix (DBM) and osteoinduction has been suggested. Extractable BMP-4 and osteoinductivity of DBM from 40 donors were assessed using enzyme-linked immunosorbent assay (ELISA) and in vivo athymic mouse assay, respectively. Extractable BMP-4 level averaged 3.7 +/- 0.21 ng/g of DBM and correlated with osteoinductivity of the DBM in an in vivo assessment of induced newbone formation.
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