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  • Title: [Simultaneous analysis of theophylline, phenobarbital, amobarbital and carbamazepine in serum by high performance liquid chromatography].
    Author: Fu S, Duan S, Ren Q.
    Journal: Se Pu; 1997 Mar; 15(2):178-9. PubMed ID: 15739418.
    Abstract:
    Theophylline, phenobarbital, amobarbital and carbamazepine are the chief therapeutic drugs in clinical practice. Because of the differences among inter-individuals in the metabolic clearance of these drugs and their toxicity at certain levels of concentration in serum, the dosage should be regulated to maintain a therapeutic blood drugs level. To achieve this a rapid and accurate assay method for drugs in blood is necessary. This paper reports that a reversed phase high performance liquid chromatographic (HPLC) method had been established for the simultaneous separation and quantitative determination of the four drugs in serum. The separation was performed on RP-C18 column using methanol:water (1:1) as mobile phase and 4-aminoantipyrime as internal standard. The eluted substances were detected at 210nm.
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