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  • Title: Total synthesis of (+)-allocyathin B2.
    Author: Trost BM, Dong L, Schroeder GM.
    Journal: J Am Chem Soc; 2005 Mar 09; 127(9):2844-5. PubMed ID: 15740107.
    Abstract:
    The first enantioselective synthesis of (+)-allocyathin was achieved. The synthesis features a Pd-catalyzed asymmetric allylic alkylation to install the first quaternary center, a Ru-catalyzed diastereoselective cycloisomerization to construct the six-membered ring, and a diastereoselective hydroxylative Knoevenagel reaction to introduce the final hydroxyl group. The unusual olefin isomerization of the Ru-catalyzed cycloisomerization was discussed and exploited for the synthesis.
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