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  • Title: [Experimental studies of lumbar spinal stenosis].
    Author: Sekiguchi M, Kikuchi S.
    Journal: Clin Calcium; 2005 Mar; 15(3):51-6. PubMed ID: 15741679.
    Abstract:
    Neurophysiologic function and ischemia causes neurogenic symptoms in lumbar spinal stenosis. Neurophysiologic function and potential therapeutic agents were investigated using a chronic cauda equina compression model that was developed according to a clinical pathogenesis. In the chronic cauda equina compression model, nerve conduction velocity and blood flow in spinal nerves decreased but mechanical allodynia was not induced. Prostaglandins and 5-HT receptor antagonist effected to improve blood flow in nerve roots after cauda equina compression;therefore, they might be potential agents for lumbar spinal stenosis.
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