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  • Title: Enantioselective chlorination and fluorination of beta-keto phosphonates catalyzed by chiral Lewis acids.
    Author: Bernardi L, Jørgensen KA.
    Journal: Chem Commun (Camb); 2005 Mar 14; (10):1324-6. PubMed ID: 15742066.
    Abstract:
    The direct chiral Lewis acidic enantioselective chlorination and fluorination of beta-keto phosphonates is presented; the chlorination proceeds in high yields and with up to 94% ee using NCS as the chloro source, while the fluorination with (PhSO2)2NF (NFSI) gives the optically active alpha-fluoro-beta-keto phosphonates in moderate to good yields and with up to 91% ee.
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