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  • Title: Activation and coreceptor expression of T lymphocytes in HIV/AIDS patients of China.
    Author: Shang H, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Ye X, Liu Y, Diao Y, Dai D, Geng W.
    Journal: J Clin Immunol; 2005 Jan; 25(1):68-72. PubMed ID: 15742159.
    Abstract:
    The objective of this paper was to investigate the activation and coreceptor CCR5, CXCR4 expression of T lymphocytes in HIV/AIDS patients of China, and to study their association with disease progression. Seventy-seven HIV/AIDS patients and thirteen normal controls were enrolled and three-color flow-cytometry was used to detect the activation marker HLA-DR, CD38 and the coreceptor CCR5, CXCR4 expression on T lymphocytes in whole blood samples taken from the patients and the controls. The HLA-DR, CD38 and CCR5 expression on CD4, CD8+ T cells in AIDS patients was higher than in asymptomatic HIV-1 infected patients and normal controls (p < 0.05); The activation and CCR5 expression on T lymphocytes significantly correlated with CD4+ T lymphocyte number and viral load. The activation on T lymphocytes and the expression of CCR5 on T lymphocytes in HIV/AIDS patients of China are significantly correlated with disease progression.
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