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  • Title: Foot-and-mouth disease control using vaccination: South African experience.
    Author: Brückner GK, Vosloo W, Cloete M, Dungu B, Du Plessis BJ.
    Journal: Dev Biol (Basel); 2004; 119():51-62. PubMed ID: 15742618.
    Abstract:
    South Africa has zoned status from the Office International des Epizooties (OIE) with the largest part of the country being foot-and-mouth disease (FMD)-free without vaccination. Outbreaks in this zone are handled differently from outbreaks in the control zones, which do not affect the export status of the country. However, the different socio-economic groupings need to be considered when reaching control decisions and in this regard, the country has been challenged with unique foot-and-mouth disease (FMD) control options. Vaccination has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone, as well as controlling outbreaks in the free zone. New adjuvants that claim to illicit longer lasting immunity have been tested with antigens derived from the SAT serotypes and animals were challenged one year post vaccination to determine the level of protection. However, even with vaccines that provide immunity for more than a year, an annual vaccination campaign will most probably not be acceptable in the buffer zone where calving occurs throughout the year.
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