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  • Title: Filariasis elimination in Egypt: impact of low microfilaraemics as sources of infection for mosquitoes.
    Author: Farid HA, Kamal SA, Weil GJ, Adham FK, Ramzy RM.
    Journal: East Mediterr Health J; 2003 Jul; 9(4):863-72. PubMed ID: 15748083.
    Abstract:
    The elimination strategy for lymphatic filariasis aims at reducing blood microfilaraemia to levels at which vector transmission cannot be sustained. We aimed to determine whether patients with pre-treatment low or ultra-low microfilaria (MF) counts could be a reservoir of infection after mass drug administration (MDA) with a combined regimen. Laboratory-reared mosquitoes were fed on 30 volunteers after 2 rounds of MDA. Microfilaria uptake, infectivity rates and number of Wuchereria bancrofti L3 per mosquito were assessed. One year after MDA-1, 6 subjects transmitted MF, but up to 9 months after MDA-2 transmission failed. Six months after MDA-2 > 90% had clear MF smears and either failed to transmit MF or transmitted MF that did not develop to L3. We conclude that the transmission cycle is seriously weakened after MDA-2.
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