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  • Title: [The study on HLA-Cw polymorphism from Xi'an Han population by PCR-sequence specific oligonucleotide probe].
    Author: Zhang HB, Lai JH, Zhao JH, Li S.
    Journal: Fa Yi Xue Za Zhi; 2004; 20(4):197-9. PubMed ID: 15751651.
    Abstract:
    OBJECTIVE: To determine the HLA-Cw allele and genotype frequencies from Xi'an Han population and obtain genetic data. METHODS: The results of HLA-Cw typing for 130 randomly selected from Xi'an Han population were obtained by using the PCR-Sequence Specific Oligonucleotide Probes (SSOP). RESULTS: In this investigation, 16 alleles were detected among 130 unrelated individuals with frequencies from 0.0077 to 0.1588 and HLA-Cw*01,03,07 were the most common HLA-Cw alleles. We have made a survey of HLA-Cw alleles frequencies in Xi'an Han Population, with blank frequency being lowered to 0.018 2. CONCLUSION: The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by Hi-square test. The frequency data can be used in forensic and paternity tests, transplant matching and anthropology.
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