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  • Title: Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura.
    Author: Wu KH, Peng CT, Li TC, Wan L, Tsai CH, Lan SJ, Chang MC, Tsai FJ.
    Journal: Br J Haematol; 2005 Mar; 128(6):849-52. PubMed ID: 15755291.
    Abstract:
    Immune thrombocytopenic purpura (ITP) is an immune-mediated disorder. We investigated the polymorphisms of interleukin (IL)-4 intron 3, IL-6 (-572 G/C), and IL-10 (-627 C/A) in 50 children with acute ITP, 30 children with chronic TIP, and 100 healthy individuals. There were significant differences in the RP1/RP2 genotype proportion (P = 0.04) and the RP2 allelic frequency (P = 0.03) of IL-4 intron 3 and the A/C genotype proportion (P = 0.01) of IL-10 (-627) between children with chronic ITP and controls. This finding suggests that the IL-4 intron 3 and IL-10 (-627) polymorphisms contribute to the susceptibility of developing childhood chronic ITP.
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