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  • Title: A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.
    Author: Sekine J, Anami M, Fujita S, Vieth M, Inokuchi T.
    Journal: Virchows Arch; 2005 Apr; 446(4):460-2. PubMed ID: 15756590.
    Abstract:
    This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.
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