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  • Title: Ultra-high resolution imaging of DNA and nucleosomes using non-contact atomic force microscopy.
    Author: Davies E, Teng KS, Conlan RS, Wilks SP.
    Journal: FEBS Lett; 2005 Mar 14; 579(7):1702-6. PubMed ID: 15757664.
    Abstract:
    Visualisation of nano-scale biomolecules aids understanding and development in molecular biology and nanotechnology. Detailed structure of nucleosomes adsorbed to mica has been captured in the absence of chemical-anchoring techniques, demonstrating the usefulness of non-contact atomic force microscopy (NC-AFM) for ultra-high resolution biomolecular imaging. NC-AFM offers significant advantages in terms of resolution, speed and ease of sample preparation when compared to techniques such as cryo-electron microscopy and X-ray crystallography. In the absence of chemical modification, detailed structure of DNA deposited on a gold substrate was observed for the first time using NC-AFM, opening up possibilities for investigating the electrical properties of unmodified DNA.
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