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  • Title: Formation of ceramide-enriched domains in lipid particles enhances the binding of apolipoprotein E.
    Author: Morita SY, Nakano M, Sakurai A, Deharu Y, Vertut-Doï A, Handa T.
    Journal: FEBS Lett; 2005 Mar 14; 579(7):1759-64. PubMed ID: 15757672.
    Abstract:
    We investigated the interaction between apolipoprotein E (apoE) and ceramide (CER)-enriched domains on the particles, by using lipid emulsions containing sphingomyelin (SM) or CER as model particles of lipoproteins. The sphingomyelinase (SMase)-induced aggregation of emulsion particles was prevented by apoE. CER increased the amount of apoE bound to emulsion particles. The confocal images of CER-containing large emulsions with two fluorescent probes showed three-dimensional microdomains enriched in CER. SMase also induced the formation of CER-enriched domains. We propose apoE prefers to bind on CER-enriched domains exposed on particle surface, and thus inhibits the aggregation or fusion of the particles.
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