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  • Title: [Visagnost--a screening test for in vitro diagnosis of allergy compared with Magic Lite and Cap-FEIA. II. Allergen-specific determination of IgE].
    Author: Rasp G.
    Journal: Laryngorhinootologie; 1992 Apr; 71(4):187-9. PubMed ID: 1575849.
    Abstract:
    Diagnosis of allergic diseases is based on medical history, clinical and specific tests. Although the role of specific IgE-determination used for allergy diagnosis is cleared, the technique might be expensive for routine screening. The development of a new dip-stick screening device (Visagnost Inhalationsallergien, in U.S. Quidel allergy screen) gives us the possibility of fast and easy screening without laboratory equipment. For the evaluation of the diagnostic value of Visagnost we compared the device with two modern standard laboratory techniques, Magic Lite SQ (Ciba-Corning) and CAP-FEIA (Pharmacia). We tested the most relevant allergens in Germany, in detail birch, grass, rye, ragweed, alternaria, cat, dog and the housedust mites D. pteronyssinus and D. farinae. We found a mean "RAST"-class of 1.55 (SD 1.25) for Magic Lite SQ, a mean of 1.24 (SD 1.62) for Visagnost and a mean of 1.93 (SD 1.70) for CAP-FEIA. Plotting the results for each of the examined methods, Magic Lite SQ seems to be more sensitive in lower specific IgE-levels, while CAP-FEIA gives more results of high IgE-levels, Visagnost ranging in between in general. Dividing the "RAST"-class results in the negative group of class 0 and 1 and in the positive group of class 2 and more, Visagnost revealed a sensitivity of 57% compared to CAP-FEIA and 63% to Magic Lite SQ, respectively. Specificity was 95.8% for CAP-FEIA and 90.7% for Magic Lite, while the positive predictive value for Magic Lite SQ was 87.9% and 95.7% for CAP-FEIA. Magic Lite gave a negative predictive value of 69.5% while 58.7% for CAP-FEIA.(ABSTRACT TRUNCATED AT 250 WORDS)
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