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  • Title: [Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats].
    Author: Xing Y, Xu ZX, Mang J, Qian JL.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2005 Mar; 17(3):174-6. PubMed ID: 15760533.
    Abstract:
    OBJECTIVE: To study the vascular endothelial growth factor (VEGF) expression and its role in focal cerebral ischemia/reperfusion injury. METHODS: VEGF protein and mRNA expressions at the site of focal ischemia/reperfusion of rat cerebrum were assessed with immunohistochemistry and hybridization techniques. RESULTS: In normal cerebral tissue there was lower expression of VEGF. It was found to be expressed in the penumbra area after ischemia. With the prolongation of ischemia and ischemia/reperfusion, enhanced expression of VEGF tended to decline to normal level, while it enhanced in the penumbra area. CONCLUSION: Enhanced VEGF expression might play a protective role in focal ischemia/reperfusion injury to the cerebrum.
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