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  • Title: Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers.
    Author: Li C, Tang Y, Armes SP, Morris CJ, Rose SF, Lloyd AW, Lewis AL.
    Journal: Biomacromolecules; 2005; 6(2):994-9. PubMed ID: 15762670.
    Abstract:
    The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiator. These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 degrees C and pH 7.4 but form free-standing physical gels at 37 degrees C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks. This gelation is reversible, and the gels are believed to contain nanosized micellar domains; this suggests possible applications in drug delivery and tissue engineering.
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