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  • Title: Solution-phase parallel synthesis of spirohydantoins.
    Author: Nieto MJ, Philip AE, Poupaert JH, McCurdy CR.
    Journal: J Comb Chem; 2005; 7(2):258-63. PubMed ID: 15762754.
    Abstract:
    Spirohydantoins are considered privileged structures, making them attractive for the preparation of compound libraries with the potential for diverse biological activity. However, very few modifications of this scaffold have been reported to date. The spirohydantoin template was elaborated into a library of 168 compounds through a two-step solution-phase parallel synthesis starting from various N-substituted piperidinones. The Strecker reaction was employed to generate alpha-amino nitriles from aniline and TMSCN (or KCN). Subsequent reaction of the anilido nitrogen with a diverse set of isocyanates, followed by refluxing under acidic conditions, afforded the title library in high yield and purity.
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