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  • Title: Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept.
    Author: Cortot AB, Cottin V, Miossec P, Fauchon E, Thivolet-Béjui F, Cordier JF.
    Journal: Respir Med; 2005 Apr; 99(4):511-4. PubMed ID: 15763460.
    Abstract:
    Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids and azathioprine. Treatment with etanercept-a tumor necrosis factor (TNF)-alpha inhibitor-combined with methotrexate, resulted in a marked improvement of both her clinical condition and pulmonary function tests. Treatment with TNF-alpha inhibitors and methotrexate may be proposed in RA-associated constrictive bronchiolitis, a severe condition hitherto not amenable to improvement.
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