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  • Title: Testosterone metabolism in normal males and male cirrhotics.
    Author: Elewaut A, Barbier F, Vermeulen A.
    Journal: Z Gastroenterol; 1979 Jul; 17(7):402-5. PubMed ID: 157639.
    Abstract:
    The following physiopathological mechanisms for the abnormalities of testosterone metabolism observed in cirrhotic patients may be postulated: 1. The decreased testosterone secretion has a primary testicular origin; it seems probable that, as a result of direct toxicity the 17-beta-reductase is inhibited, resulting in decrease of testosterone and an increase of androstenedione. 2. The hypothalamic-pituitary function is nearly normal in cirrhotics. Basal level of LH and FSH are often slightly elevated, indicating a normal reactivity of the pituitary. 3. The conversion of androgens to oestrogens (androstenedione to oestrone) which occurs essentially extrahepatically, is increaed in cirrhosis.
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