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  • Title: [Development of purified HFRS bivalent vaccine].
    Author: Yang SL, Dong GM, Li J, An Q, Sun XD, Sun XH, Li P.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2005 Mar; 21(2):243-5. PubMed ID: 15766416.
    Abstract:
    AIM: To develop the purified HFRS bivalent vaccine. METHODS: LR1 (type I) and R22 (type II) of HFRS virus were cultured respectively in Vero cells. The viral suspensions were harvested, inactivated with beta-propiolactone, concentrated by ultra-filtration, purified by zone centrifugation, and desucrosed by column chromatography. The qualified vaccine bulks of type I and type II were mixed equally and absorbed with AI(OH)3 for preparation of 3 lots vaccines. RESULTS: The 3 lots vaccines all passed examination carried out by ourselves and reexamination performed by National Institute for the Control of Pharmaceutical and Biological Products . One of 3 lots has been used in clinical trial. CONCLUSION: It is practical to develop the purified HFRS bivalent vaccine by Vero cell culture.
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