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  • Title: [An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells].
    Author: Fu KF, Peng RY, Gao YB, Wang DW, Luo QL, Yang Y, Dong B.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2005 Mar; 21(2):250-3. PubMed ID: 15766418.
    Abstract:
    AIM: To observe the effect of ionizing radiation on intestinal epithelial cells 6 (IEC-6) and the effect of IL-2 on the proliferation and recovery of radiation-injured IEC-6 cells. METHODS: IEC-6 cells exposed to 4, 8 and 12 Gy gamma ray were analyzed with MTT colorimetry, light microscopy, electron microscopy, DNA gel electrophoresis and flow cytometry at 3, 6, 9, 12 hours and 1, 2, 3 days after radiation. Proliferation of 8 Gy gamma ray-irradiated IEC-6 cells which was treated with IL-2 was detected by MTT colorimetry at 3, 6, 9, 12 and 24 hours after irradiation. RESULTS: Proliferation of IEC-6 decreased with the increased dose of gamma ray radiation. Apoptotic IEC-6 cells increased apparently at 24 hours after radiation with 8.0 Gy gamma ray, IL-2 could enhance the proliferation of irradiated IEC-6 cells (especially at concentration of 1 x 10(5) U/L) in a dose-dependent manner. CONCLUSION: 4-12 Gy of gamma ray radiation can reduce the proliferation and cause apoptosis of IEC-6 cells. IL-2 can accelerate proliferation of irradiated IEC-6 cells and protect IECs from ionization radiation injury.
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