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  • Title: A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide.
    Author: Arosio D, Fontanella M, Baldini L, Mauri L, Bernardi A, Casnati A, Sansone F, Ungaro R.
    Journal: J Am Chem Soc; 2005 Mar 23; 127(11):3660-1. PubMed ID: 15771476.
    Abstract:
    A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.
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