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  • Title: Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs.
    Author: Sasaki E, Kojima H, Nishimatsu H, Urano Y, Kikuchi K, Hirata Y, Nagano T.
    Journal: J Am Chem Soc; 2005 Mar 23; 127(11):3684-5. PubMed ID: 15771488.
    Abstract:
    Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.
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