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  • Title: [New therapeutic strategies in ANCA-associated systemic vasculitis].
    Author: Ruiz FL, Bart PA.
    Journal: Rev Med Suisse; 2005 Jan 05; 1(1):19-23. PubMed ID: 15773192.
    Abstract:
    High-dose corticosteroids in combination with cytotoxic drugs are universally accepted as the initial treatment in ANCA-associated vasculitis. Cyclophosphamide is the most effective cytotoxic drug and is used in more severe cases. Because of short- and long-term side-effects, novel therapies have been tested. New prospects for the treatment of vasculitis include sequential chemotherapy (e.g. cyclophosphamide followed by azathioprine or cyclophosphamide followed by methotrexate) and/or novel immunosuppressive agents (e.g. mycophenolate mofetil, anti-TNF-alpha).
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