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  • Title: [Effect of the corticoliberin fragment CRF(4-6) on blood pressure and heart rate in rats].
    Author: Makarenko EIu, Andreeva LA, Borovik AS, Mart'ianov AA.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2005 Jan; 91(1):71-9. PubMed ID: 15773582.
    Abstract:
    The effects of tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) on blood pressure and heart rate of rats were investigated. Intracerebroventricularly injected CRF(4-6) (1.5-15.0 nmol/head) increases the mean arterial pressure and heart rate in conscious and anaesthetized animals in a dose-dependent manner. Corticotropin releasing factor antagonist: alpha-helical CRF(9-41) (6.5 nmol) completely abolished the influence of tripeptide CRF(4-6) (1.5 nmol) on blood pressure and heart rate in anaesthetized rats. This result indicates that corticoliberin receptors are involved in cardiovascular effects of CRF(4-6).
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