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  • Title: Syndecans: new kids on the signaling block.
    Author: Tkachenko E, Rhodes JM, Simons M.
    Journal: Circ Res; 2005 Mar 18; 96(5):488-500. PubMed ID: 15774861.
    Abstract:
    Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.
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