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  • Title: Synthesis and antitumor activity of 4'-O-acylanthracyclines.
    Author: Nakajima S, Kawai H, Komeshima N, Sakakibara M, Tatsuta K, Otake N, Umezawa H.
    Journal: J Antibiot (Tokyo); 1992 Mar; 45(3):374-9. PubMed ID: 1577664.
    Abstract:
    4'-O-Acyl derivatives of doxorubicin, daunorubicin, 13-deoxocarminomycin, 13-deoxo-10-hydroxycarminomycin, 13-deoxo-11-deoxycarminomycin were synthesized through the formation and mild acid hydrolysis of 2-oxazoline intermediates. The antitumor activity of these 4'-O-acyl derivatives against P388 leukemia was similar to or more effective than the parent anthracyclines.
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