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  • Title: Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: a pilot study.
    Author: Watson S, Thompson JM, Malik N, Ferrier IN, Young AH.
    Journal: Aust N Z J Psychiatry; 2005 Apr; 39(4):244-8. PubMed ID: 15777360.
    Abstract:
    OBJECTIVE: To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder. METHOD: We examined HPA axis function in a pilot study of five patients with rapid-cycling bipolar disorder in both relapse and remission using the dexamethasone/corticotropin releasing hormone (dex/CRH) test. RESULTS: The cortisol response to the dex/CRH test correlated significantly between the 2 tests (r = 0.997; p < 0.0005). CONCLUSION: The data suggests that the cortisol response to the dex/CRH test is stable over time and independent of mood state.
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