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  • Title: Managing inflammatory reaction to restylane.
    Author: Soparkar CN, Patrinely JR.
    Journal: Ophthalmic Plast Reconstr Surg; 2005 Mar; 21(2):151-3. PubMed ID: 15778672.
    Abstract:
    A 62-year-old woman received injections of Restylane, cross-linked hyaluronic acid, for the cosmetic filling of facial rhytids and developed a severe dermal inflammatory reaction. Hyaluronidase administered directly in the inflammatory nodules resulted in rapid resolution of pain, palpable nodularity, and visible induration possibly due to dissolution of the hyaluronic acid.
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