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  • Title: [Further purification of a tissue specific inhibitor in lymphopoiesis (lymphocyte chalone?) (author's transl)].
    Author: Heidemann E, Jung A, Masurczak J, Podgornik N, Schmidt H, Wilms K.
    Journal: Blut; 1979 Aug; 39(2):99-106. PubMed ID: 157789.
    Abstract:
    A partially purified calf spleen extract, which exhibits the properties of a lymphocyte chalone (tissue-specific, species non-specific, non-toxic and reversible acting, endogenous inhibitor of cell proliferation) as concerning biological activities, has been described earlier. This fraction has been further purified by ion exchange chromatography with DEAE-Sephacel to a 10,000-fold purification. The most active fraction inhibited 3H-thymidine incorporation into phytohemagglutinin- or pokeweed-mitogen-stimulated lymphocytes by 86% resp. 70%, when given in a concentration of 100 ng/ml. Ehrlich-ascites-cells were not inhibited by the same concentration. The inhibiting activity is compared to other published lymphocyte inhibitors.
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