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  • Title: Antimutagenicity of milk cultured with lactic acid bacteria against N-methyl-N'-nitro-N-nitrosoguanidine.
    Author: Hosoda M, Hashimoto H, Morita H, Chiba M, Hosono A.
    Journal: J Dairy Sci; 1992 Apr; 75(4):976-81. PubMed ID: 1578035.
    Abstract:
    The antimutagenic effect of cultured milk using 71 strains of lactic acid bacteria belonging to the genus Lactobacillus, Streptococcus, Lactococcus, and Bifidobacterium on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine was investigated in vitro using Salmonella typhimurium TA 100 as an indicator bacterium. Each cultured milk sample displayed its characteristic antimutagenic effect on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. The milk cultured with Lactobacillus acidophilus LA 106 (LA2) showed the highest inhibition of 77% against the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine among the strains tested. Changes in the antimutagenic effect of the milk cultured by Lb. acidophilus LA 106 (LA2) during incubation were also examined using N-methyl-N'-nitro-N-nitrosoguanidine as a mutagen.
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