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  • Title: Biosensors based on binding-modulated donor-acceptor distances.
    Author: Fan C, Plaxco KW, Heeger AJ.
    Journal: Trends Biotechnol; 2005 Apr; 23(4):186-92. PubMed ID: 15780710.
    Abstract:
    The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both electron transfer and energy transfer are strongly dependent on donor-acceptor distance. When coupled with the large conformational changes sometimes associated with biomolecular recognition, these distance-dependent processes provide a robust means for generating optical and electronic signals.
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