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  • Title: Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia.
    Author: Zhang HL, Huang ZH, Zhu Y, Liang ZQ, Han R, Wang XX, Chase TN, Qin ZH.
    Journal: Brain Res; 2005 Mar 28; 1039(1-2):203-6. PubMed ID: 15781063.
    Abstract:
    The present study evaluated the neuroprotective potential of prostaglandin A1 (PGA1) in rodent models of focal cerebral ischemia. PGA1 33 nmol reduced infarction volume by about 43% (P < 0.05) when administered intracerebroventricularly before and after transient ischemia in mice. PGA1 16.5-66 nmol diminished infarction volume by 18% to 27% (P < 0.01) when administered immediately following permanent ischemia in rats. PGA1 treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA1 protects neurons from ischemic injury.
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