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  • Title: Motion detection in normal infants and young patients with infantile esotropia.
    Author: Bosworth RG, Birch EE.
    Journal: Vision Res; 2005 Jun; 45(12):1557-67. PubMed ID: 15781073.
    Abstract:
    The purpose of this study was to investigate asymmetries in detection of horizontal motion in normal infants and children and in patients with infantile esotropia. Motion detection thresholds (% motion signal) were measured in 75 normal infants and in 36 eyes of 27 infants with infantile esotropia (ET), using a forced-choice preferential looking paradigm with random-dot patterns. Absolute motion detection sensitivity and asymmetries in sensitivity for nasalward (N) vs. temporalward (T) directions of motion were compared in normal and patient populations, ranging in age from 1 month to 5 years. In normal infants, N and T thresholds were equivalent under 2.5 months of age, whereas a superiority for monocular detection of N motion was observed between 3.5 and 6.5 months of age. The nasalward advantage gradually diminished to symmetrical T:N performance by 8 months of age, matching that of adults. No asymmetry was observed in 15 normal infants who performed the task binocularly, hence, the asymmetry was not a leftward/rightward bias. In the youngest infantile ET patients tested, at 5 months of age, a nasalward superiority in motion detection was observed and was equivalent to that of same-age normal infants. However, unlike normals, this asymmetry persists in older patients. This greater asymmetry in infantile ET represents worse detection of T than N motion. This is the first report of an asymmetry in motion detection in normal infants across a wide age range. Initially, motion detection is normal in infants with infantile esotropia. Cumulative abnormal binocular experience in these patients may disrupt motion mechanisms.
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