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  • Title: Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates.
    Author: Balaz M, Holmes AE, Benedetti M, Rodriguez PC, Berova N, Nakanishi K, Proni G.
    Journal: J Am Chem Soc; 2005 Mar 30; 127(12):4172-3. PubMed ID: 15783190.
    Abstract:
    The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3' end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 A), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.
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