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  • Title: Coupled dynamics of voltage and calcium in paced cardiac cells.
    Author: Shiferaw Y, Sato D, Karma A.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Feb; 71(2 Pt 1):021903. PubMed ID: 15783348.
    Abstract:
    We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
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