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  • Title: Effect of molecular mass on antitumor activity of heteropolysaccharide from Poria cocos.
    Author: Zhang L, Chen L, Xu X, Zeng F, Cheung PC.
    Journal: Biosci Biotechnol Biochem; 2005 Mar; 69(3):631-4. PubMed ID: 15784995.
    Abstract:
    A water-soluble heteropolysaccharide ac-PCM0 from Poria cocos was successfully fractionated using a preparative size exclusion chromatography (SEC) column, and their weight-average molecular mass (M(w)) was characterized by analytical SEC combined with laser light scattering (SEC-LLS). The results indicate that the fractions having relatively high M(w) exhibited higher inhibition ratio in vivo antitumor activity than those having M(w) below 3.29 x 10(4). However, the relatively low molecular mass was beneficial to the in vitro antitumor activity. Moreover, ac-PCM0 has a significantly higher enhancement ratio of the body weight than 5-fluorouracil, and its 50% lethal dose is above 1250 mg/kg, indicating a nontoxic nature.
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