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  • Title: Anti-invasive activity of niacin and trigonelline against cancer cells.
    Author: Hirakawa N, Okauchi R, Miura Y, Yagasaki K.
    Journal: Biosci Biotechnol Biochem; 2005 Mar; 69(3):653-8. PubMed ID: 15785001.
    Abstract:
    The effects of niacin, namely, nicotinic acid and nicotinamide, and trigonelline on the proliferation and invasion of cancer cells were studied using a rat ascites hepatoma cell line of AH109A in culture. Niacin and trigonelline inhibited the invasion of hepatoma cells at concentrations of 2.5-40 microM without affecting proliferation. Hepatoma cells previously cultured with a reactive oxygen species (ROS)-generating system showed increased invasive activity. Niacin and trigonelline suppressed this ROS-potentiated invasive capacity through simultaneous treatment of AH109A cells with the ROS-generating system. The present study indicates for the first time the anti-invasive activities of niacin and trigonelline against cancer cells.
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